ATP MODULATES THE FUNCTION OF INOSITOL 1,4,5-TRISPHOSPHATE-GATED CHANNELS AT 2 SITES

被引：157

作者：

BEZPROZVANNY, I ^{[1
]}

EHRLICH, BE ^{[1
]}

机构：

[1] MARINE BIOL LAB, WOODS HOLE, MA 02543 USA

来源：

NEURON | 1993年 / 10卷 / 06期

关键词：

D O I：

10.1016/0896-6273(93)90065-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The inositol 1,4,5-trisphosphate (IP3) receptor, a Ca2+-permeable channel, plays a key role in intracellular Ca2+ signaling. The effects of ATP on the IP3 receptor at the single-channel level were characterized after channel incorporation into planar lipid bilayers. ATP alone was not sufficient to open the IP3-gated channel, but addition of ATP or nonhydrolyzable ATP analogs in the presence of IP3 increased the frequency of channel openings 4.8-fold and increased the average duration of channel openings 2.5-fold; channel conductance was unchanged. High concentrations of ATP (>4 mM) decreased channel activity most probably by competing with IP3 for the IP3-binding site. Allosteric modulation of IP3-induced Ca2+ release by ATP may contribute to the maintenance of cell viability during periods of energy starvation.

引用

页码：1175 / 1184

页数：10

共 37 条

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