PROTEIN KINASES .5. PROTEIN-KINASE-C AND LIPID SIGNALING FOR SUSTAINED CELLULAR-RESPONSES

被引：2335

作者：

NISHIZUKA, Y ^{[1
]}

机构：

[1] KOBE UNIV, SCH MED, DEPT BIOCHEM, KOBE 657, JAPAN

来源：

FASEB JOURNAL | 1995年 / 9卷 / 07期

关键词：

DIACYLGLYCEROL; FATTY ACID; LYSOPHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASES;

D O I：

10.1096/fasebj.9.7.7737456

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since the second messenger role was proposed for the products of inositol phospholipid hydrolysis, considerable progress has been made in our understanding of the biochemical mechanism of the intracellular signaling network. It is now becoming evident that stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. Many of their metabolites have potentials to induce, intensify, and prolong the activation of protein kinase C that is needed for sustained cellular responses.

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收藏

页码：484 / 496

页数：13

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