CORTICOSTERONE INCREASES FGF-2 (BFGF) IMMUNOREACTIVITY IN THE SUBSTANTIA-NIGRA OF THE RAT

被引：43

作者：

CHADI, G

ROSEN, L

CINTRA, A

TINNER, B

ZOLI, M

PETTERSSON, RF

FUXE, K

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN

[2] UNIV MODENA,DEPT HUMAN PHYSIOL,I-41100 MODENA,ITALY

[3] LUDWIG INST CANC RES,STOCKHOLM,SWEDEN

来源：

NEUROREPORT | 1993年 / 4卷 / 06期

关键词：

FIBROBLAST GROWTH FACTOR; BASIC; SUBSTANTIA-NIGRA; DOPAMINE; CORTICOSTERONE; IMMUNOCYTOCHEMISTRY; IMAGE ANALYSIS;

D O I：

10.1097/00001756-199306000-00047

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effects of acute and subchronic (7 days) administrations of the adrenocortical hormone corticosterone on basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity were studied in the substantia nigra of the rat by semiquantitative immunocytochemistry coupled with image analysis. Corticosterone was able to increase FGF-2 immunoreactivity in different nigral subregions and cell types (astrocytes and neurones) depending on the duration of the treatment. These results open up the possibility that stress hormones can modulate the trophic state of the substantia nigra through an action on FGF-2.

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页码：783 / 786

页数：4

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