BASIC FGF IS PRESENT IN DOPAMINERGIC-NEURONS OF THE VENTRAL MIDBRAIN OF THE RAT

被引：74

作者：

CINTRA, A

CAO, YH

OELLIG, C

TINNER, B

BORTOLOTTI, F

GOLDSTEIN, M

PETTERSSON, RF

FUXE, K

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,BOX 60400,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA INST,LUDWIG INST CANC RES,S-10401 STOCKHOLM 60,SWEDEN

[3] NYU MED CTR,NEW YORK,NY 10016

来源：

NEUROREPORT | 1991年 / 2卷 / 10期

关键词：

FIBROBLAST GROWTH FACTOR; BASIC; SUBSTANTIA-NIGRA; DOPAMINE; IMMUNOCYTOCHEMISTRY; RNA BLOT ANALYSIS;

D O I：

10.1097/00001756-199110000-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IMMUNOCYTOCHEMISTRY procedures and 6-hydroxydopamine-induced degeneration of dopamine nerve cells provided evidence that practically all tyrosine hydroxylase immunoreactive (IR) neurons of the substantia nigra and ventral tegmental area contain cytoplasmic basic fibroblast growth factor immunoreactivity (bFGF IR), while many astroglial cells in the neostriatum and substantia nigra contain nuclear bFGF IR. RNA blot analysis demonstrated strong expression of a major 3.7 kb bFGF mRNA in the substantia nigra and ventral tegmental area. These results indicate that bFGF may be a significant growth factor in the DA neurons.

引用

页码：597 / 600

页数：4

共 16 条

[1] GANGLIOSIDES INCREASE THE SURVIVAL OF LESIONED NIGRAL DOPAMINE NEURONS AND FAVOR THE RECOVERY OF DOPAMINERGIC SYNAPTIC FUNCTION IN STRIATUM OF RATS BY COLLATERAL SPROUTING [J].