INVOLVEMENT OF THE AMYGDALA IN THE MEMORY-ENHANCING EFFECTS OF CLENBUTEROL

被引：92

作者：

INTROINICOLLISON, IB ^{[1
]}

MIYAZAKI, B ^{[1
]}

MCGAUGH, JL ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRVINE, CA 92717 USA

来源：

PSYCHOPHARMACOLOGY | 1991年 / 104卷 / 04期

关键词：

MEMORY; CLENBUTEROL; STRIA TERMINALIS; AMYGDALA; NOREPINEPHRINE;

D O I：

10.1007/BF02245663

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Male Sprague Dawley rats with stria terminalis (ST) or sham lesions were trained in an inhibitory avoidance task, injected immediately post-training with clenbuterol hydrochloride (0.03 mg/kg; IP), and tested for retention 48 h later. Clenbuterol enhanced retention of the sham-lesioned animals but did not affect retention of the ST-lesioned animals. Clenbuterol injected intra-amygdally immediately after training also enhanced retention of the inhibitory avoidance task. These results agree with other evidence suggesting the participation of beta-noradrenergic mechanisms in the amygdala in the modulation of memory storage.

引用

页码：541 / 544

页数：4

共 27 条

[11] NALOXONE ENHANCEMENT OF MEMORY PROCESSES - EFFECTS OF OTHER OPIATE ANTAGONISTS [J].

GALLAGHER, M .

BEHAVIORAL AND NEURAL BIOLOGY, 1982, 35 (04) :375-382

[12]

Gallagher M., 1981, AMYGDALOID COMPLEX, P343

[13]

HALL H, 1980, ACTA PHARMACOL TOX, V47, P159

[14] MEMORY ENHANCEMENT WITH INTRA-AMYGDALA POST-TRAINING NALOXONE IS BLOCKED BY CONCURRENT ADMINISTRATION OF PROPRANOLOL [J].

INTROINICOLLISON, IB ;

NAGAHARA, AH ;

MCGAUGH, JL .

BRAIN RESEARCH, 1989, 476 (01) :94-101

[15] OPIOID PEPTIDERGIC SYSTEMS MODULATE THE ACTIVITY OF BETA-ADRENERGIC MECHANISMS DURING MEMORY CONSOLIDATION PROCESSES [J].

INTROINICOLLISON, IB ;

BARATTI, CM .

BEHAVIORAL AND NEURAL BIOLOGY, 1986, 46 (02) :227-241

[16]

INTROINICOLLISON IB, 1989, PSYCHOBIOLOGY, V17, P397

[17]

INTROINICOLLISON IB, 1991, NEUR CONT B, V6, P275

[18] INVOLVEMENT OF AMYGDALA PATHWAYS IN THE INFLUENCE OF POST-TRAINING INTRAAMYGDALA NOREPINEPHRINE AND PERIPHERAL EPINEPHRINE ON MEMORY STORAGE [J].

LIANG, KC ;

MCGAUGH, JL ;

YAO, HY .

BRAIN RESEARCH, 1990, 508 (02) :225-233

[19] MODULATING EFFECTS OF POST-TRAINING EPINEPHRINE ON MEMORY - INVOLVEMENT OF THE AMYGDALA NORADRENERGIC SYSTEM [J].

LIANG, KC ;

JULER, RG ;

MCGAUGH, JL .

BRAIN RESEARCH, 1986, 368 (01) :125-133

[20] LESIONS OF THE STRIA TERMINALIS ATTENUATE THE AMNESTIC EFFECT OF AMYGDALOID STIMULATION ON AVOIDANCE RESPONSES [J].

LIANG, KC ;

MCGAUGH, JL .

BRAIN RESEARCH, 1983, 274 (02) :309-318

← 1 2 3 →