DIFFERENTIAL INTERACTIONS OF REL-NF-KAPPA-B COMPLEXES WITH I-KAPPA-B-ALPHA DETERMINE POOLS OF CONSTITUTIVE AND INDUCIBLE NF-KAPPA-B ACTIVITY

被引:114
作者
DOBRZANSKI, P [1 ]
RYSECK, RP [1 ]
BRAVO, R [1 ]
机构
[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,DEPT MOLEC BIOL,PRINCETON,NJ 08543
关键词
GENE REGULATION; I-KAPPA-B-ALPHA INTERACTION; REL NF-KAPPA-B COMPLEX; TRANSCRIPTION FACTOR;
D O I
10.1002/j.1460-2075.1994.tb06782.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Rel-NF-kappa B family of transcription factors plays a crucial role in the regulation of genes involved in inflammatory and immune responses. We demonstrate that in vivo, in contrast to the other members of the family, RelB associates efficiently only with NF-kappa B1 (p105-p50) and NF-kappa B2 (p100-p52), but not with cRel or p65. The RelB-p52 heterodimers display a much lower affinity for I kappa B alpha than RelB-p50 heterodimers or p65 complexes. However, similarly to the other Rel-NF-kappa B complexes, RelB-p52 can upregulate the synthesis of I kappa B alpha leading to the cytoplasmic trapping of dimers which have a higher affinity for the inhibitor. We suggest that a hierarchy of interactions between I kappa B alpha and the different Rel-NF-kappa B complexes governs their cellular distribution. This results in the presence of two distinct pools of NF-kappa B activity which differ in their composition: one a constitutive nuclear and the other an inducible cytoplasmic activity.
引用
收藏
页码:4608 / 4616
页数:9
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