NF-KAPPA-B AND RELATED PROTEINS - REL DORSAL HOMOLOGIES MEET ANKYRIN-LIKE REPEATS

被引：399

作者：

BLANK, V

KOURILSKY, P

ISRAEL, A

机构：

[1] Unité de Biologie Moléculaire du Gène, U, 277 INSERM, U.A. 535 CNRS, Institut Pasteur, 25 rue du Dr Roux

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 04期

关键词：

D O I：

10.1016/0968-0004(92)90321-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular cloning of the subunits of the transcription factor NF-kappa-B and its inhibitor I-kappa-B revealed regions of sequence homology with two different classes of proteins: the Rel/dorsal family and a heterogeneous group of proteins containing ankyrin-like repeats. Both the Rel/dorsal homology domain and the ankyrin-like repeats appear to play important roles in protein-protein interactions that regulate localization and activity of the NF-kappa-B subunits.

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页码：135 / 140

页数：6

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