DECREASED PROLIFERATION, INTERLEUKIN-2 SYNTHESIS, AND INTERLEUKIN-2 RECEPTOR EXPRESSION ARE ACCOMPANIED BY DECREASED MESSENGER-RNA EXPRESSION IN PHYTOHEMAGGLUTININ-STIMULATED CELLS FROM ELDERLY DONORS

被引：245

作者：

NAGEL, JE ^{[1
]}

CHOPRA, RK ^{[1
]}

CHREST, FJ ^{[1
]}

MCCOY, MT ^{[1
]}

SCHNEIDER, EL ^{[1
]}

HOLBROOK, NJ ^{[1
]}

ADLER, WH ^{[1
]}

机构：

[1] NIA,GERONTOL RES CTR,MOLEC GENET LAB,BALTIMORE,MD 21224

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1988年 / 81卷 / 04期

关键词：

D O I：

10.1172/JCI113422

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

引用

页码：1096 / 1102

页数：7

共 47 条

[1]

ARYA SK, 1984, J IMMUNOL, V133, P273

[2]

BICHTHUY LT, 1987, J IMMUNOL, V139, P1550

[3] TRANSIENT EXPRESSION OF INTERLEUKIN-2 RECEPTORS - CONSEQUENCES FOR T-CELL GROWTH [J].

CANTRELL, DA ;

SMITH, KA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (06) :1895-1911

[4] THE INTERLEUKIN-2 T-CELL SYSTEM - A NEW CELL-GROWTH MODEL [J].

CANTRELL, DA ;

SMITH, KA .

SCIENCE, 1984, 224 (4655) :1312-1316

[5] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[6] REGULATION OF INTERLEUKIN-2 RECEPTOR EXPRESSION AND RECEPTOR RELEASE [J].

DIAMANTSTEIN, T ;

OSAWA, H ;

MOUZAKI, A ;

JOSIMOVICALASEVIC, O .

MOLECULAR IMMUNOLOGY, 1986, 23 (11) :1165-1172

[7] A 2ND HUMAN INTERLEUKIN-2 BINDING-PROTEIN THAT MAY BE A COMPONENT OF HIGH-AFFINITY INTERLEUKIN-2 RECEPTORS [J].

DUKOVICH, M ;

WANO, Y ;

THUY, LTB ;

KATZ, P ;

CULLENS, BR ;

KEHRL, JH ;

GREENE, WC .

NATURE, 1987, 327 (6122) :518-522

[8] A TECHNIQUE FOR RADIOLABELING DNA RESTRICTION ENDONUCLEASE FRAGMENTS TO HIGH SPECIFIC ACTIVITY [J].

FEINBERG, AP ;

VOGELSTEIN, B .

ANALYTICAL BIOCHEMISTRY, 1983, 132 (01) :6-13

[9] IMMUNOLOGICAL STUDIES OF AGING - DECREASED PRODUCTION OF AND RESPONSE TO T-CELL GROWTH-FACTOR BY LYMPHOCYTES FROM AGED HUMANS [J].

GILLIS, S ;

KOZAK, R ;

DURANTE, M ;

WEKSLER, ME .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 67 (04) :937-942

[10]

GILLIS S, 1978, J IMMUNOL, V120, P2027

← 1 2 3 4 5 →