THE ENIGMA OF THE NATURAL-KILLER-CELL

被引：239

作者：

GUMPERZ, JE ^{[1
]}

PARHAM, P ^{[1
]}

机构：

[1] STANFORD UNIV, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA

来源：

NATURE | 1995年 / 378卷 / 6554期

关键词：

D O I：

10.1038/378245a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants. Whereas human NK cell class I receptors consist of immunoglobulin domains, their mouse counterparts resemble C-type lectins. This difference may reflect the receptors' diverse and rapidly evolving class I ligands.

引用

页码：245 / 248

页数：4

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