MOLECULAR-BIOLOGY OF SOMATOSTATIN RECEPTORS

被引：345

作者：

BELL, GI

REISINE, T

机构：

[1] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

[3] UNIV PENN,SCH MED,DEPT PHARMACOL,PHILADELPHIA,PA 19104

来源：

TRENDS IN NEUROSCIENCES | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1016/0166-2236(93)90050-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide somatostatin (SRIF) has diverse Physiological actions in the brain and endocrine organs. A family of SRIF receptors has recently been cloned that may mediate the distinct biological effects of SRIF. These receptors have a high degree of amino acid sequence similarity among themselves, but their sequences are different from any other receptors, indicating that they represent a distinct neurotransmitter receptor subfamily. The availability of the cloned receptors will now allow for detailed structure-function analysis of SRIF receptors and will facilitate development of subtype-selective agonists and antagonists that could be useful in the treatment of central nervous system and endocrine disorders.

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页码：34 / 38

页数：5

相关论文

共 40 条

[1]

BARBER DL, 1989, J BIOL CHEM, V264, P21038

[2]

BREDER CD, 1992, J NEUROSCI, V12, P3920

[3] SOMATOSTATIN RECEPTORS ARE EXPRESSED BY IMMATURE CEREBELLAR GRANULE CELLS - EVIDENCE FOR A DIRECT INHIBITORY EFFECT OF SOMATOSTATIN ON NEUROBLAST ACTIVITY [J].

GONZALEZ, B ;

LEROUX, P ;

LAMACZ, M ;

BODENANT, C ;

BALAZS, R ;

VAUDRY, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9627-9631

[4] ONTOGENY OF SOMATOSTATIN RECEPTORS IN THE RAT-BRAIN - BIOCHEMICAL AND AUTORADIOGRAPHIC STUDY [J].

GONZALEZ, BJ ;

LEROUX, P ;

BODENANT, C ;

LAQUERRIERE, A ;

COY, DH ;

VAUDRY, H .

NEUROSCIENCE, 1989, 29 (03) :629-644

[5] CYSTEAMINE-INDUCED DEPLETION OF CENTRAL SOMATOSTATIN-LIKE IMMUNOACTIVITY - EFFECTS ON BEHAVIOR, LEARNING, MEMORY AND BRAIN NEUROCHEMISTRY [J].

HAROUTUNIAN, V ;

MANTIN, R ;

CAMPBELL, GA ;

TSUBOYAMA, GK ;

DAVIS, KL .

BRAIN RESEARCH, 1987, 403 (02) :234-242

[6] SOMATOSTATIN DEPRESSES EXCITABILITY IN NEURONS OF THE SOLITARY TRACT COMPLEX THROUGH HYPERPOLARIZATION AND AUGMENTATION OF IM, A NON-INACTIVATING VOLTAGE-DEPENDENT OUTWARD CURRENT BLOCKED BY MUSCARINIC AGONISTS [J].

JACQUIN, T ;

CHAMPAGNAT, J ;

MADAMBA, S ;

DENAVITSAUBIE, M ;

SIGGINS, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (03) :948-952

[7] ASSIGNMENT OF G-PROTEIN SUBTYPES TO SPECIFIC RECEPTORS INDUCING INHIBITION OF CALCIUM CURRENTS [J].

KLEUSS, C ;

HESCHELER, J ;

EWEL, C ;

ROSENTHAL, W ;

SCHULTZ, G ;

WITTIG, B .

NATURE, 1991, 353 (6339) :43-48

[8] EXPRESSION CLONING OF A RAT-BRAIN SOMATOSTATIN RECEPTOR CDNA [J].

KLUXEN, FW ;

BRUNS, C ;

LUBBERT, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4618-4622

[9] SOMATOSTATIN INHIBITS THE ACTIVITY OF ADENYLATE-CYCLASE IN CULTURED HUMAN MENINGIOMA CELLS AND STIMULATES THEIR GROWTH [J].

KOPER, JW ;

MARKSTEIN, R ;

KOHLER, C ;

KWEKKEBOOM, DJ ;

AVEZAAT, CJJ ;

LAMBERTS, SWJ ;

REUBI, JC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (03) :543-547

[10]

LAW S, 1991, J BIOL CHEM, V268, P17885

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