AN RNA POLYMERASE-II TRANSCRIPTION FACTOR SHARES FUNCTIONAL-PROPERTIES WITH ESCHERICHIA-COLI SIGMA-70

被引:79
作者
CONAWAY, JW
CONAWAY, RC
机构
[1] Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104
关键词
D O I
10.1126/science.2193400
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A mammalian transcription factor, which, along with other factors, is essential for accurate initiation of transcription from promoters by RNA polymerase II, has been found to regulate the interaction of polymerase and DNA. This factor, designated βγ, drastically reduces the affinity of RNA polymerase II for free DNA containing either promoter or nonpromoter sequences. In this respect, βγ functions as does the bacterial transcription initiation factor σ70, which expedites the binding of Escherichia coli RNA polymerase to promoters in part by accelerating dissociation of the polymerase from nonpromoter sites in DNA.
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页码:1550 / 1553
页数:4
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