DECREASED EXPRESSION OF HEAT-SHOCK PROTEIN-70 MESSENGER-RNA AND PROTEIN AFTER HEAT-TREATMENT IN CELLS OF AGED RATS

被引：183

作者：

FARGNOLI, J

KUNISADA, T

FORNACE, AJ

SCHNEIDER, EL

HOLBROOK, NJ

机构：

[1] NIA,MOLEC GENET LAB,4940 EASTERN AVE,BALTIMORE,MD 21224

[2] NCI,RADIAT ONCOL BRANCH,BETHESDA,MD 20892

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 02期

关键词：

aging; stress;

D O I：

10.1073/pnas.87.2.846

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of aging on the induction of heat shock protein 70 (HSP70)-encoding gene expression by elevated temperatures was studied in cultures of lung- or skin-derived fibroblasts from young (5 mo) and old (24 mo) male Wistar rats. Although the kinetics of the heat shock response were found to be similar in the two age groups, we observed lower levels of induction of HSP70 mRNA and HSP70 protein in confluent primary lung and skin fibroblast cultures derived from aged animals. Additional experiments with freshly excised lung tissue showed a similar age-related decline in the heat-induced expression of HSP70.

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页码：846 / 850

页数：5

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