EFFECT OF ACUTE INFLAMMATORY LUNG INJURY ON THE EXPRESSION OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) IN RAT PULMONARY ALVEOLAR MACROPHAGES

被引：67

作者：

BRIELAND, JK ^{[1
]}

JONES, ML ^{[1
]}

CLARKE, SJ ^{[1
]}

BAKER, JB ^{[1
]}

WARREN, JS ^{[1
]}

FANTONE, JC ^{[1
]}

机构：

[1] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48104

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 1992年 / 7卷 / 02期

关键词：

D O I：

10.1165/ajrcmb/7.2.134

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using a well-characterized rat model of immune complex-mediated acute inflammatory lung injury, we determined that there is a time-dependent elaboration of monocyte chemotactic activity in bronchoalveolar lavage fluid. Monocyte chemotactic activity is also significantly enhanced in culture supernatants from pulmonary alveolar macrophages (PAMs) from injured rat lungs. Northern hybridization analysis revealed markedly increased expression of rat monocyte chemoattractant protein 1 (MCP-1) mRNA in PAMs obtained from rats with immune complex-induced lung injury. The increased expression of MCP-1 mRNA and associated increase in monocyte chemotactic activity present in culture supernatants of PAMs from injured rat lungs suggest that PAMs may participate in the pathogenesis of acute inflammatory lung injury by the secretion of monocyte chemoattractants including MCP-1.

引用

页码：134 / 139

页数：6

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