ADMINISTRATION OF ANTIGRANULOCYTE MONOCLONAL-ANTIBODY RB6-8C5 PREVENTS EXPRESSION OF ACQUIRED-RESISTANCE TO LISTERIA-MONOCYTOGENES INFECTION IN PREVIOUSLY IMMUNIZED MICE

被引：61

作者：

CZUPRYNSKI, CJ ^{[1
]}

BROWN, JF ^{[1
]}

WAGNER, RD ^{[1
]}

STEINBERG, H ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT PATHOBIOL SCI,MADISON,WI 53706

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 11期

关键词：

D O I：

10.1128/IAI.62.11.5161-5163.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have established the importance of neutrophils in innate resistance to Listeria monocytogenes infection in mice, The purpose of this study was to determine the importance of neutrophils in acquired resistance to L. monocytogenes infection. Previously immunized mice that were depleted of neutrophils by administration of the antigranulocyte monoclonal antibody RB6-8C5 demonstrated less resistance to L. monocytogenes challenge than did nonimmunized control mice. In contrast, immunized control mice exhibited a heightened resistance to rechallenge, as expected. These results suggest that neutrophils make previously unrecognized contributions to acquired immunity to a facultative intracellular pathogen.

引用

页码：5161 / 5163

页数：3

共 26 条

[1] EARLY PATHOGENESIS OF INFECTION IN THE LIVER WITH THE FACULTATIVE INTRACELLULAR BACTERIA LISTERIA-MONOCYTOGENES, FRANCISELLA-TULARENSIS, AND SALMONELLA-TYPHIMURIUM INVOLVES LYSIS OF INFECTED HEPATOCYTES BY LEUKOCYTES [J].

CONLAN, JW ;

NORTH, RJ .

INFECTION AND IMMUNITY, 1992, 60 (12) :5164-5171

[2] LEUKOCYTE-MEDIATED LYSIS OF INFECTED HEPATOCYTES DURING LISTERIOSIS OCCURS IN MICE DEPLETED OF NK CELLS OR CD4+ CD8+ THY1.2+ T-CELLS [J].

CONLAN, JW ;

DUNN, PL ;

NORTH, RJ .

INFECTION AND IMMUNITY, 1993, 61 (06) :2703-2707

[3] NEUTROPHIL-MEDIATED DISSOLUTION OF INFECTED HOST-CELLS AS A DEFENSE STRATEGY AGAINST A FACULTATIVE INTRACELLULAR BACTERIUM [J].

CONLAN, JW ;

NORTH, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (03) :741-744

[4] NEUTROPHILS ARE ESSENTIAL FOR EARLY ANTI-LISTERIA DEFENSE IN THE LIVER, BUT NOT IN THE SPLEEN OR PERITONEAL-CAVITY, AS REVEALED BY A GRANULOCYTE-DEPLETING MONOCLONAL-ANTIBODY [J].

CONLAN, JW ;

NORTH, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (01) :259-268

[5]

CZUPRYNSKI CJ, 1985, J IMMUNOL, V134, P3449

[6]

CZUPRYNSKI CJ, 1984, J LEUKOCYTE BIOL, V35, P193

[7]

CZUPRYNSKI CJ, 1994, J IMMUNOL, V152, P1836

[8]

DJEU JY, 1990, BLOOD, V76, P1405

[9] EARLY GAMMA INTERFERON-PRODUCTION BY NATURAL-KILLER-CELLS IS IMPORTANT IN DEFENSE AGAINST MURINE LISTERIOSIS [J].

DUNN, PL ;

NORTH, RJ .

INFECTION AND IMMUNITY, 1991, 59 (09) :2892-2900

[10] DEPRESSION OF IMMUNITY TO NAEGLERIA-FOWLERI IN MICE BY SELECTIVE DEPLETION OF NEUTROPHILS WITH A MONOCLONAL-ANTIBODY [J].

FERRANTE, A ;

CARTER, RF ;

LOPEZ, AF ;

ROWANKELLY, B ;

HILL, N ;

VADAS, MA .

INFECTION AND IMMUNITY, 1988, 56 (09) :2286-2291

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