IDENTIFICATION OF A 2ND PSEUDOAUTOSOMAL REGION NEAR THE XQ AND YQ TELOMERES

被引：151

作者：

FREIJE, D

HELMS, C

WATSON, MS

DONISKELLER, H

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT SURG,DIV HUMAN MOLEC GENET,660 S EUCLID ST,ST LOUIS,MO 63110

[2] WASHINGTON UNIV,SCH MED,EDWARD MALLINCKRODT DEPT PEDIAT,ST LOUIS,MO 63110

[3] WASHINGTON UNIV,SCH MED,DEPT GENET,ST LOUIS,MO 63110

[4] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO 63110

来源：

SCIENCE | 1992年 / 258卷 / 5089期

关键词：

D O I：

10.1126/science.1465614

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The telomeres of Xq and Yq have been observed to associate during meiosis, and in rare cases a short synaptonemal complex is present. Molecular cloning of loci from Xqter and Yqter has revealed that their sequence homology extends over 400 kilobases, which suggests the possibility of genetic exchange. This hypothesis was tested by the development of two highly informative microsatellite markers from yeast artificial chromosome clones that carried Xqter sequences and the following of their inheritance in a set of reference pedigrees from the Centre d'Etude du Polymorphisme Humain in Paris, France. From a total of 195 informative male meioses, four recombination events between these loci were observed. In three cases, paternal X alleles were inherited by male offspring, and in one case a female offspring inherited her father's Y allele. These data support the existence of genetic exchange at Xq-Yq, which defines a second pseudoautosomal region between the sex chromosomes.

引用

页码：1784 / 1787

页数：4

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