MOLECULAR-CLONING OF A NOVEL LAMININ CHAIN, ALPHA-5, AND WIDESPREAD EXPRESSION IN ADULT-MOUSE TISSUES

被引：226

作者：

MINER, JH ^{[1
]}

LEWIS, RM ^{[1
]}

SANES, JR ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 48期

关键词：

D O I：

10.1074/jbc.270.48.28523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a fifth member of the alpha subfamily of vertebrate laminin chains. Sequence analysis revealed a close relationship of alpha 5 to the only known Drosophila alpha chain, suggesting that the ancestral alpha gene was more similar to alpha 5 than to alpha 1-4. Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae.

引用

页码：28523 / 28526

页数：4

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