REDUCTION OF DELAYED NEURONAL DEATH BY INHIBITION OF PROTEIN-SYNTHESIS

被引：181

作者：

SHIGENO, T

YAMASAKI, Y

KATO, G

KUSAKA, K

MIMA, T

TAKAKURA, K

GRAHAM, DI

FURUKAWA, S

机构：

[1] TAIHO PHARMACEUT CO LTD,RES INST,TOKUSHIMA,JAPAN

[2] UNIV TOKYO,DEPT NEUROSURG,TOKYO 113,JAPAN

[3] CHIBA COLL HLTH SCI,DEPT ANAT,CHIBA,JAPAN

[4] UNIV GLASGOW,DEPT NEUROPATHOL,GLASGOW G12 8QQ,SCOTLAND

[5] NATL INST NEUROSCI,DEPT NEUROIMMUNOL,TOKYO,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

关键词：

Anisomycin; Cerebral ischemia; Delayed neuronal death; Hippocampus; Killer protein; Nerve growth factor;

D O I：

10.1016/0304-3940(90)90182-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed 'killer protein' is required, possibly due to deprivation of nerve growth factor or other trophic factors. © 1990.

引用

页码：117 / 119

页数：3

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