REDUCTION OF DELAYED NEURONAL DEATH BY INHIBITION OF PROTEIN-SYNTHESIS

被引：181

作者：

SHIGENO, T

YAMASAKI, Y

KATO, G

KUSAKA, K

MIMA, T

TAKAKURA, K

GRAHAM, DI

FURUKAWA, S

机构：

[1] TAIHO PHARMACEUT CO LTD,RES INST,TOKUSHIMA,JAPAN

[2] UNIV TOKYO,DEPT NEUROSURG,TOKYO 113,JAPAN

[3] CHIBA COLL HLTH SCI,DEPT ANAT,CHIBA,JAPAN

[4] UNIV GLASGOW,DEPT NEUROPATHOL,GLASGOW G12 8QQ,SCOTLAND

[5] NATL INST NEUROSCI,DEPT NEUROIMMUNOL,TOKYO,JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 01期

关键词：

Anisomycin; Cerebral ischemia; Delayed neuronal death; Hippocampus; Killer protein; Nerve growth factor;

D O I：

10.1016/0304-3940(90)90182-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brief forebrain ischemia in rodents causes delayed neuronal death selectively in the CA1 pyramidal cells of hippocampus. Treatment with a reversible protein synthesis inhibitor, anisomycin, significantly reduced the occurrence of delayed neuronal death in the Mongolian gerbil. This result indicates that de novo synthesis of certain protein(s), collectively termed 'killer protein' is required, possibly due to deprivation of nerve growth factor or other trophic factors. © 1990.

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页码：117 / 119

页数：3

相关论文

共 17 条

[1] NMDA RECEPTORS TRIGGER EXCITEMENT [J].

BARNES, DM .

SCIENCE, 1988, 239 (4837) :254-256

[2] CELLS WITHOUT GROWTH-FACTORS COMMIT SUICIDE [J].

BARNES, DM .

SCIENCE, 1988, 242 (4885) :1510-1511

[3]

Bradley P M, 1988, Brain Res, V468, P243

[4] SMALL DIFFERENCES IN INTRAISCHEMIC BRAIN TEMPERATURE CRITICALLY DETERMINE THE EXTENT OF ISCHEMIC NEURONAL INJURY [J].

BUSTO, R ;

DIETRICH, WD ;

GLOBUS, MYT ;

VALDES, I ;

SCHEINBERG, P ;

GINSBERG, MD .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1987, 7 (06) :729-738

[5] SYNTHESIS OF HEAT-SHOCK PROTEINS IN RAT-BRAIN CORTEX AFTER TRANSIENT ISCHEMIA [J].

DIENEL, GA ;

KIESSLING, M ;

JACEWICZ, M ;

PULSINELLI, WA .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1986, 6 (04) :505-510

[6] LONG-TERM POTENTIATION INDUCED IN DENDRITES SEPARATED FROM RATS CA1 PYRAMIDAL SOMATA DOES NOT ESTABLISH A LATE PHASE [J].

FREY, U ;

KRUG, M ;

BRODEMANN, R ;

REYMANN, K ;

MATTHIES, H .

NEUROSCIENCE LETTERS, 1989, 97 (1-2) :135-139

[7] DELAYED C-FOS PROTO-ONCOGENE EXPRESSION IN THE RAT HIPPOCAMPUS INDUCED BY TRANSIENT GLOBAL CEREBRAL-ISCHEMIA - AN INSITU HYBRIDIZATION STUDY [J].

JORGENSEN, MB ;

DECKERT, J ;

WRIGHT, DC ;

GEHLERT, DR .

BRAIN RESEARCH, 1989, 484 (1-2) :393-398

[8] DELAYED NEURONAL DEATH IN THE GERBIL HIPPOCAMPUS FOLLOWING ISCHEMIA [J].

KIRINO, T .

BRAIN RESEARCH, 1982, 239 (01) :57-69

[9] IMPAIRMENT OF PROTEIN UBIQUITINATION MAY CASE DELAYED NEURONAL DEATH [J].

MAGNUSSON, K ;

WIELOCH, T .

NEUROSCIENCE LETTERS, 1989, 96 (03) :264-270

[10] INHIBITORS OF PROTEIN-SYNTHESIS AND RNA-SYNTHESIS PREVENT NEURONAL DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION [J].

MARTIN, DP ;

SCHMIDT, RE ;

DISTEFANO, PS ;

LOWRY, OH ;

CARTER, JG ;

JOHNSON, EM .

JOURNAL OF CELL BIOLOGY, 1988, 106 (03) :829-844