ROLE OF OXIDIZED LOW-DENSITY-LIPOPROTEIN IN ATHEROGENESIS

被引：2403

作者：

WITZTUM, JL

STEINBERG, D

机构：

[1] UCSD Dept. of Medicine 0613-D, La Jolla, CA 92093-0613

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1991年 / 88卷 / 06期

关键词：

D O I：

10.1172/JCI115499

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Evidence to support an important role of oxidative modification in mediating the atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox-LDL or products of Ox-LDL can affect many components of the atherogenic process, including vasomotor properties and thrombosis, as well as lesion initiation and progression itself. These ideas suggest new approaches, that in combination with lowering of plasma cholesterol, could lead to the prevention of atherosclerosis and its complications.

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页码：1785 / 1792

页数：8

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