QUANTITATIVE ASPECTS OF REACTIVE GLIOSIS - A REVIEW

被引：503

作者：

NORTON, WT

AQUINO, DA

HOZUMI, I

CHIU, FC

BROSNAN, CF

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PATHOL,BRONX,NY 10461

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 09期

关键词：

GLIOSIS; ASTROCYTES; GFAP; BRAIN DAMAGE; DEMYELINATION;

D O I：

10.1007/BF00993263

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies of gliosis in a variety of animal models are reviewed. The models include brain injury, neurotoxic damage, genetic diseases and inflammatory demyelination. These studies show that reactive gliosis is not a stereotypic response, but varies widely in duration, degree of hyperplasia, and time course of expression of GFAP immunostaining, content and mRNA. We conclude that there are different biological mechanisms for induction and maintenance of reactive gliosis, which, depending on the kind of tissue damage, result in different expressions of the gliotic response.

引用

页码：877 / 885

页数：9

共 79 条

[31] ASTROCYTIC REACTIVITY AND INTERMEDIATE FILAMENT METABOLISM IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS - THE EFFECT OF SUPPRESSION WITH PRAZOSIN [J].