SERUM INTERLEUKIN-6 LEVELS BECOME ELEVATED IN ACUTE MYOCARDIAL-INFARCTION

被引：152

作者：

IKEDA, U

OHKAWA, F

SEINO, Y

YAMAMOTO, K

HIDAKA, Y

KASAHARA, T

KAWAI, T

SHIMADA, K

机构：

[1] JICHI MED SCH, DEPT MED BIOL & PARASITOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[2] JICHI MED SCH, DEPT CLIN PATHOL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1992年 / 24卷 / 06期

关键词：

INTERLEUKIN-6; CREATINE KINASE; MESSENGER RNA; MYOCARDIAL INFARCTION; CRP;

D O I：

10.1016/0022-2828(92)91042-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have examined serum interleukin 6 (IL-6) levels in 12 patients with acute myocardial infarction (AMI). IL-6 levels became elevated in all patients, following the rise of serum creatine kinase (CK) activity. Peak IL-6 levels showed a good correlation with peak serum C-reactive protein (CRP) levels, while there was no direct relationship between peak IL-6 levels and peak CK activity. IL-6 mRNA was not detected in unstimulated "quiescent" rat cardiocytes cultured in serum-free medium, but its expression was induced by exposure of the cells to serum or ionomycin. These results show that IL-6 is synthesized in the myocardium and serum IL-6 levels become elevated in AMI, suggesting that IL-6 could affect the progression and/or healing processes of AMI. © 1992.

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收藏

页码：579 / 584

页数：6

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