DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE (MPTP) IN THE MOUSE - RELATIONSHIPS BETWEEN MONOAMINE-OXIDASE, MPTP METABOLISM AND NEUROTOXICITY

被引:99
作者
HEIKKILA, RE [1 ]
HESS, A [1 ]
DUVOISIN, RC [1 ]
机构
[1] UNIV MED & DENT NEW JERSEY,RUTGERS MED SCH,DEPT ANAT,PISCATAWAY,NJ 08854
关键词
D O I
10.1016/0024-3205(85)90064-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:231 / 236
页数:6
相关论文
共 12 条
[1]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[2]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[3]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[4]   NEUROTOXICITY OF THE MEPERIDINE ANALOG N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
OLSON, L ;
JONSSON, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 97 (1-2) :133-136
[5]   DOPAMINERGIC NEUROTOXICITY OF 1-METHYL-4-PHENYL-1,2,5,6-TETRAHYDROPYRIDINE IN MICE [J].
HEIKKILA, RE ;
HESS, A ;
DUVOISIN, RC .
SCIENCE, 1984, 224 (4656) :1451-1453
[6]  
HEIKKILA RE, 1984, NATURE, V311, P467, DOI 10.1038/311467a0
[7]   CHRONIC PARKINSONISM IN HUMANS DUE TO A PRODUCT OF MEPERIDINE-ANALOG SYNTHESIS [J].
LANGSTON, JW ;
BALLARD, P ;
TETRUD, JW ;
IRWIN, I .
SCIENCE, 1983, 219 (4587) :979-980
[8]  
LANGSTON JW, 1984, BRAIN RES, V292, P390
[9]   INTRANEURONAL GENERATION OF A PYRIDINIUM METABOLITE MAY CAUSE DRUG-INDUCED PARKINSONISM [J].
MARKEY, SP ;
JOHANNESSEN, JN ;
CHIUEH, CC ;
BURNS, RS ;
HERKENHAM, MA .
NATURE, 1984, 311 (5985) :464-467
[10]   PARTIAL PURIFICATION OF MONOAMINE OXIDASE FROM RAT BRAIN [J].
SEIDEN, LS ;
WESTLEY, J .
BIOCHIMICA ET BIOPHYSICA ACTA, 1962, 58 (02) :363-&