CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS

被引：1139

作者：

DAVIS, GC

WILLIAMS, AC

MARKEY, SP

EBERT, MH

CAINE, ED

REICHERT, CM

KOPIN, IJ

机构：

[1] Glenn C. Davis, M.D., is Associate Professor of Psychiatry, University of Tennessee Center for the Health Sciences

[2] Michael H. Ebert, M.D., is Chief, Section on Experimental Therapeutics, LCS, NIMH

[3] Cheryl M. Reichert, M.D., Ph.D., is Resident, Department of Pathology, National Cancer Institute, NIH

[4] Irwin J. Kopin, M.D., id Chief, LCS, NIMH

来源：

PSYCHIATRY RESEARCH | 1979年 / 1卷 / 03期

关键词：

biogenic amines; drug-induced; Parkinsonism; substantia nigra;

D O I：

10.1016/0165-1781(79)90006-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener, produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor disturbances, the syndrome perisited for 18 months and responded to drugs that stimulate dopamine receptors. Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra. © 1979.

引用

页码：249 / 254

页数：6

共 4 条

[1]

Berger, Ziering, Lee, Piperidine derivatives: Part IV. 4-Alkyl-4- and 4-hetero-cyclyl-piperidines, Journal of Organic Chemistry, 12, (1947)

[2]

Caine, Ebert, Weingartner, An outline for the analysis of dementia, Neurology, 270, (1977)

[3]

Janssen, Eddy, Compounds related to pethidine—IV. New general chemical methods of increasing the analgesic activity of pethidine, Journal of Medicinal and Pharmaceutical Chemistry, 2, (1960)

[4]

Ziering, Berger, Heineman, Lee, Piperidine derivatives: Part III. 4-Aryl-piperidines, Journal of Organic Chemistry, 12, (1947)

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