MAST-CELLS AS A SOURCE OF MULTIFUNCTIONAL CYTOKINES

被引：687

作者：

GORDON, JR

BURD, PR

GALLI, SJ

机构：

[1] BETH ISRAEL HOSP, CHARLES A DANA RES INST, BOSTON, MA 02215 USA

[2] NIAID, BETHESDA, MD 20892 USA

[3] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0167-5699(90)90176-A

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mast cells have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, immunologically non-specific inflammatory and fibrotic conditions, angiogenesis, and tissue remodeling and wound healing. However, the molecular basis for the action of the mast cell in many of these responses is obscure. In this review, John Gordon, Parris Burd and Stephen Galli suggest that the production of a broad panel of multifunctional cytokines may represent an important mechanism by which mast cells influence physiological, immunological and pathological processes.

引用

页码：458 / 464

页数：7

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