THE INFLUENCE OF ISOLATION AND AMINOOXYACETIC ACID (AOAA) ON GABA IN MURICIDAL RATS

被引：17

作者：

BOLIN, P ^{[1
]}

DAVANZO, JP ^{[1
]}

机构：

[1] E CAROLINA UNIV, SCH MED, DEPT PHARMACOL, GREENVILLE, NC 27834 USA

来源：

PSYCHOPHARMACOLOGY | 1982年 / 76卷 / 04期

关键词：

D O I：

10.1007/BF00449126

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of isolation was studied on the development of muricidal behavior and on brain GABA. GABA was significantly lower in several parts of the limbic system of brain taken from muricidal rats, when compared to their non-muricidal counterparts. Isolated potentiated the development of muricidal behavior and lowered GABA levels. Administration of [the GABA-transaminase inhibitor] aminooxyacetic acid (AOAA) resulted in a preferential elevation of GABA in the olfactory lobes. Muricidal behavior was inhibited during the AOAA-induced increase in GABA.

引用

页码：367 / 370

页数：4

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