INHIBITION OF ISOLATION-INDUCED AGGRESSIVE-BEHAVIOR WITH GABA TRANSAMINASE INHIBITORS

被引：35

作者：

DAVANZO, JP ^{[1
]}

SYDOW, M ^{[1
]}

机构：

[1] E CAROLINA UNIV, SCH MED, GREENVILLE, NC 27834 USA

来源：

PSYCHOPHARMACOLOGY | 1979年 / 62卷 / 01期

关键词：

γ-Acetylenic GABA; Aminooxyacetic acid; GABA; Isolation-induced aggressive behavior;

D O I：

10.1007/BF00426030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Administration of aminooxyacetic acid (AOAA) and .gamma.-acetylenic GABA (GAG) resulted in a dose-dependent suppression of aggressive behavior and a concomitant increase in brain GABA in mice. The increase in GABA levels persisted beyond the time when AOAA and GAG exerted an anti-aggressive effect. Brain GABA levels remained significantly elevated over controls for 120 h after a single AOAA injection and 46 h after a single GAG dose.

引用

收藏

页码：23 / 27

页数：5

相关论文

共 28 条

[1]

BAXTER CF, 1960, P SOC EXP BIOL MED, V104, P426

[2] EFFECTS OF MICRO-INJECTIONS OF L-GLUTAMATE INTO HYPOTHALAMUS ON ATTACK AND FLIGHT BEHAVIOUR IN CATS [J].

BRODY, JF ;

DEFEUDIS, PA ;

DEFEUDIS, FV .

NATURE, 1969, 224 (5226) :1330-&

[3] FIGHTING IN MICE - ONTOGENETIC AND EXPERIENTIAL DETERMINANTS [J].

CAIRNS, RB ;

NAKELSKI, JS .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1971, 74 (03) :354-&

[4] EFFECTS OF DRUGS ON BEHAVIOR [J].

COOK, L ;

KELLEHER, RT .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1963, 3 :205-&

[5] PHARMACOLOGICAL AND BIOCHEMICAL STUDIES IN ISOLATION-INDUCED FIGHTING MICE [J].

DAVANZO, JP ;

DAUGHERTY, M ;

RUCKART, R ;

KANG, L .

PSYCHOPHARMACOLOGIA, 1966, 9 (03) :210-210

[6] ANTICONVULSANT PROPERTIES OF AMINO-OXYACETIC ACID [J].

DAVANZO, JP ;

CRONIN, MA ;

GREIG, ME .

AMERICAN JOURNAL OF PHYSIOLOGY, 1961, 201 (05) :833-&

[7]

DAVANZO JP, 1969, P S BIOLOGY AGGRESSI, P263

[8] BINDING OF GLYCINE AND GAMMA-AMINOBUTYRIC ACID TO SYNAPTOSOMAL FRACTIONS OF BRAINS OF DIFFERENTIALLY-HOUSED MICE [J].

DEFEUDIS, FV ;

MADTES, P ;

GERVASCAMACHO, J .

EXPERIMENTAL NEUROLOGY, 1976, 50 (01) :207-213

[9] DEVELOPMENT OF STANDARD STIMULUS ANIMALS FOR MOUSE (MUS-MUSCULUS) AGGRESSION TESTING BY MEANS OF OLFACTORY BULBECTOMY [J].

DENENBERG, VH ;

GAULINKR.E ;

GANDELMAN, R ;

ZARROW, MX .

ANIMAL BEHAVIOUR, 1973, 21 (AUG) :590-598

[10] EFFECT OF TESTOSTERONE AND CYPROTERONE-ACETATE ON CONCENTRATION OF GAMMA-AMINOBUTYRIC ACID IN BRAIN AREAS OF AGGRESSIVE AND NON-AGGRESSIVE MICE [J].

EARLEY, CJ ;

LEONARD, BE .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1977, 6 (04) :409-413