A PHYSICAL MAP AND CANDIDATE GENES IN THE BRCA1 REGION ON CHROMOSOME 17Q12-21

被引：89

作者：

ALBERTSEN, HM

SMITH, SA

MAZOYER, S

FUJIMOTO, E

STEVENS, J

WILLIAMS, B

RODRIGUEZ, P

CROPP, CS

SLIJEPCEVIC, P

CARLSON, M

ROBERTSON, M

BRADLEY, P

LAWRENCE, E

HARRINGTON, T

SHENG, ZM

HOOPES, R

STERNBERG, N

BROTHMAN, A

CALLAHAN, R

PONDER, BAJ

WHITE, R

机构：

[1] UNIV UTAH,HOWARD HUGHES MED INST,SALT LAKE CITY,UT 84112

[2] UNIV CAMBRIDGE,DEPT PATHOL,CRC,HUMAN CANC GENET RES GRP,CAMBRIDGE CB2 1QP,ENGLAND

[3] NCI,TUMOR IMMUNOL & BIOL LAB,BETHESDA,MD 20892

[4] DUPONT MERCK PHARMACEUT CO,WILMINGTON,DE 19880

来源：

NATURE GENETICS | 1994年 / 7卷 / 04期

关键词：

D O I：

10.1038/ng0894-472

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have constructed a physical map of a 4 cM region on chromosome 17q12-21 that contains the hereditary breast and ovarian cancer gene BRCA1. The map comprises a contig of 137 overlapping yeast artificial chromosomes and P1 clones, onto which we have placed 112 PCR markers. We have localized more than 20 genes on this map, ten of which had not been mapped to the region previously, and have isolated 30 cDNA clones representing partial sequences of as yet unidentified genes. Two genes that lie within a narrow region defined by meiotic breakpoints in BRCA1 patients have been sequenced in breast cancer patients without revealing any deleterious mutations. These new reagents should facilitate the identification of BRCA1.

引用

页码：472 / 479

页数：8

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[11] LOCALIZATION OF LOW-MOLECULAR-WEIGHT GTP BINDING-PROTEINS TO EXOCYTIC AND ENDOCYTIC COMPARTMENTS [J].