THE POLYMORPHIC HUMAN DNA-SEQUENCE D8S8 ASSIGNED TO 8Q13-21.1, CLOSE TO THE CARBONIC-ANHYDRASE GENE-CLUSTER, BY ISOTOPIC AND NONISOTOPIC INSITU HYBRIDIZATION AND BY LINKAGE ANALYSIS

被引：6

作者：

EDWARDS, Y

WILLIAMS, S

WEST, L

LIPOWICZ, S

SHEER, D

ATTWOOD, J

SPURR, N

SARKAR, R

SAHA, N

POVEY, S

机构：

[1] IMPERIAL CANC RES FUND, LONDON WC2A 3PX, ENGLAND

[2] IMPERIAL CANC RES FUND, POTTERS BAR EN6 3LD, HERTS, ENGLAND

[3] UNIV LONDON UNIV COLL, GALTON LAB, DEPT GENET & BIOMETRY, LONDON NW1 2HE, ENGLAND

[4] NATL UNIV SINGAPORE, DEPT PEDIAT, SINGAPORE 0511, SINGAPORE

来源：

ANNALS OF HUMAN GENETICS | 1990年 / 54卷

关键词：

D O I：

10.1111/j.1469-1809.1990.tb00369.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Restriction fragment length polymorphism at the D8S8 locus is explained by the occurrence of at least two alternative alleles at two separate TaqI sites; Taql‐A allele frequencies 0–73 and 0–27 and Taql‐B allele frequencies 0–94 and 0–06. The D8S8 locus has been assigned to 8q 13–21.1, near to the carbonic anhydrase CA gene cluster, by in situ hybridization to metaphase chromosomes using both tritium and immunofluorescently labelled probes. Linkage analysis using the CEPH family DNA panel indicates a close genetic linkage between D8S8 and CA3, with a lod score of + 7–80 at TH – 0.05 in males. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：131 / +

页数：1

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