SHORT-TERM SCREENING-TESTS FOR CARCINOGENS

被引：149

作者：

BRIDGES, BA ^{[1
]}

机构：

[1] UNIV SUSSEX, CELL MUTATION UNIT, BRIGHTON BN1 9QG, SUSSEX, ENGLAND

来源：

NATURE | 1976年 / 261卷 / 5557期

关键词：

D O I：

10.1038/261195a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are now short term tests with a high predictive value for mammalian carcinogens. Many of them are based on the ability to detect damage to DNA in bacteria or mammalian cells after metabolic activation by microsomal enzymes. Their introduction will enable provisional safety assessments to be made for the many thousands of industrial and environmental chemicals for which long-term animal testing cannot be considered.

引用

页码：195 / 200

页数：6

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