ROLE OF THE EXCITATORY AMINO-ACID RECEPTORS IN THE MEDIATION OF THE NOCICEPTIVE RESPONSE TO FORMALIN IN THE RAT

被引：80

作者：

HUNTER, JC

SINGH, L

机构：

[1] Department of Biology, Parke-Davis Neuroscience Research Centre, Addenbrookes Hospital Site, Cambridge, CB2 2QB, Hills Road

来源：

NEUROSCIENCE LETTERS | 1994年 / 174卷 / 02期

关键词：

CENTRAL NERVOUS SYSTEM; PAIN; AMPA; GLYCINE MODULATORY SITE; N-METHYL-D-ASPARTATE; INFLAMMATION;

D O I：

10.1016/0304-3940(94)90025-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The relative contribution of the NMDA/glycine allosteric site and non-NMDA (AMPA) types of glutamate receptor to the acute and tonic phases of the behavioural nociceptive response to formalin has been studied in the rat. The AMPA receptor selective antagonist NBQX preferentially inhibited the acute phase indicating that AMPA receptors may be involved in mediating fast acute nociceptive transmission in the dorsal horn. In contrast, the strychnine-insensitive glycine site partial agonist (+)-HA-966 and the NMDA competitive antagonist CGS 19755 preferentially attenuated the tonic nociceptive phase. However, none of these compounds exhibited anti-inflammatory properties. Thus, both NMDA and non-NMDA antagonists can selectively block changes in neuronal excitability while tissue injury in the receptive field continues to evolve.

引用

页码：217 / 221

页数：5

共 20 条

[11] ANTINOCICEPTIVE ACTIONS OF DIFFERENT CLASSES OF EXCITATORY AMINO-ACID RECEPTOR ANTAGONISTS IN MICE [J].

NASSTROM, J ;

KARLSSON, U ;

POST, C .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 212 (01) :21-29

[12] A COMPARISON OF THE ACTIONS OF AGONISTS AND ANTAGONISTS AT NON-NMDA RECEPTORS OF C-FIBERS AND MOTONEURONS OF THE IMMATURE RAT SPINAL-CORD INVITRO [J].

POOK, P ;

BRUGGER, F ;

HAWKINS, NS ;

CLARK, KC ;

WATKINS, JC ;

EVANS, RH .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (01) :179-184

[13] THE FORMALIN TEST IN MICE - EFFECT OF FORMALIN CONCENTRATION [J].

ROSLAND, JH ;

TJOLSEN, A ;

MAEHLE, B ;

HOLE, K .

PAIN, 1990, 42 (02) :235-242

[14] 2,3-DIHYDROXY-6-NITRO-7-SULFAMOYL-BENZO(F)QUINOXALINE - A NEUROPROTECTANT FOR CEREBRAL-ISCHEMIA [J].

SHEARDOWN, MJ ;

NIELSEN, EO ;

HANSEN, AJ ;

JACOBSEN, P ;

HONORE, T .

SCIENCE, 1990, 247 (4942) :571-574

[15] ENANTIOMERS OF HA-966 (3-AMINO-1-HYDROXYPYRROLID-2-ONE) EXHIBIT DISTINCT CENTRAL NERVOUS-SYSTEM EFFECTS - (+)-HA-966 IS A SELECTIVE GLYCINE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST, BUT (-)-HA-966 IS A POTENT GAMMA-BUTYROLACTONE-LIKE SEDATIVE [J].

SINGH, L ;

DONALD, AE ;

FOSTER, AC ;

HUTSON, PH ;

IVERSEN, LL ;

IVERSEN, SD ;

KEMP, JA ;

LEESON, PD ;

MARSHALL, GR ;

OLES, RJ ;

PRIESTLEY, T ;

THORN, L ;

TRICKLEBANK, MD ;

VASS, CA ;

WILLIAMS, BJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) :347-351

[16] EXTRACELLULAR AMINO-ACID CONCENTRATIONS IN THE DORSAL SPINAL-CORD OF FREELY MOVING RATS FOLLOWING VERATRIDINE AND NOCICEPTIVE STIMULATION [J].

SKILLING, SR ;

SMULLIN, DH ;

BEITZ, AJ ;

LARSON, AA .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (01) :127-132

[17] THE FORMALIN TEST - AN EVALUATION OF THE METHOD [J].

TJOLSEN, A ;

BERGE, OG ;

HUNSKAAR, S ;

ROSLAND, JH ;

HOLE, K .

PAIN, 1992, 51 (01) :5-17

[18] THE BEHAVIORAL-EFFECTS OF MK-801 - A COMPARISON WITH ANTAGONISTS ACTING NON-COMPETITIVELY AND COMPETITIVELY AT THE NMDA RECEPTOR [J].

TRICKLEBANK, MD ;

SINGH, L ;

OLES, RJ ;

PRESTON, C ;

IVERSEN, SD .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (01) :127-135

[19] NMDA RECEPTOR ANTAGONISTS, MK-801 AND ACEA-1011, PREVENT THE DEVELOPMENT OF TONIC PAIN FOLLOWING SUBCUTANEOUS FORMALIN [J].

VACCARINO, AL ;

MAREK, P ;

KEST, B ;

WEBER, E ;

KEANA, JFW ;

LIEBESKIND, JC .

BRAIN RESEARCH, 1993, 615 (02) :331-334

[20] STANDARDIZATION OF THE RAT PAW FORMALIN TEST FOR THE EVALUATION OF ANALGESICS [J].

WHEELERACETO, H ;

COWAN, A .

PSYCHOPHARMACOLOGY, 1991, 104 (01) :35-44

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