PROTEIN-KINASE-C DIRECTLY PHOSPHORYLATES THE INSULIN-RECEPTOR INVITRO AND REDUCES ITS PROTEIN-TYROSINE KINASE-ACTIVITY

被引：271

作者：

BOLLAG, GE ^{[1
]}

ROTH, RA ^{[1
]}

BEAUDOIN, J ^{[1
]}

MOCHLYROSEN, D ^{[1
]}

KOSHLAND, DE ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PHARMACOL,STANFORD,CA 94305

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1986年 / 83卷 / 16期

关键词：

D O I：

10.1073/pnas.83.16.5822

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：5822 / 5824

页数：3

共 24 条

[11]

KAHN CR, 1985, ANNU REV MED, V36, P429

[12]

KIKKAWA U, 1982, J BIOL CHEM, V257, P13341

[13] PHORBOL ESTER INHIBITION OF HORMONAL INDUCTION OF TYROSINE AMINOTRANSFERASE [J].

KOONTZ, JW ;

GOODMAN, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 131 (02) :815-820

[14] PURIFICATION AND CHARACTERIZATION OF A CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE FROM RAT-BRAIN [J].

KURET, J ;

SCHULMAN, H .

BIOCHEMISTRY, 1984, 23 (23) :5495-5504

[15] INSULIN-RECEPTOR TYROSINE KINASE IS DEFECTIVE IN SKELETAL-MUSCLE OF INSULIN-RESISTANT OBESE MICE [J].

LEMARCHANDBRUSTEL, Y ;

GREMEAUX, T ;

BALLOTTI, R ;

VANOBBERGHEN, E .

NATURE, 1985, 315 (6021) :676-679

[16] ASSOCIATION OF PHORBOL ESTER-INDUCED HYPERPHOSPHORYLATION AND REVERSIBLE REGULATION OF TRANSFERRIN MEMBRANE-RECEPTORS IN HL60 CELLS [J].

MAY, WS ;

JACOBS, S ;

CUATRECASAS, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :2016-2020

[17] INSULIN ACTION IS BLOCKED BY A MONOCLONAL-ANTIBODY THAT INHIBITS THE INSULIN-RECEPTOR KINASE [J].

MORGAN, DO ;

HO, L ;

KORN, LJ ;

ROTH, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (02) :328-332

[18] THE ROLE OF PROTEIN KINASE-C IN CELL-SURFACE SIGNAL TRANSDUCTION AND TUMOR PROMOTION [J].

NISHIZUKA, Y .

NATURE, 1984, 308 (5961) :693-698

[19] HOW INSULIN RESISTANT ARE PATIENTS WITH NONINSULIN-DEPENDENT DIABETES-MELLITUS [J].

REAVEN, GM ;

CHEN, YDI ;

DONNER, CC ;

FRAZE, E ;

HOLLENBECK, CB .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 61 (01) :32-36

[20] INSULIN-RECEPTOR - EVIDENCE THAT IT IS A PROTEIN-KINASE [J].

ROTH, RA ;

CASSELL, DJ .

SCIENCE, 1983, 219 (4582) :299-301

← 1 2 3 →