NITRIC-OXIDE SYNTHASE PROTEIN AND MESSENGER-RNA ARE DISCRETELY LOCALIZED IN NEURONAL POPULATIONS OF THE MAMMALIAN CNS TOGETHER WITH NADPH DIAPHORASE

被引：1306

作者：

BREDT, DS

GLATT, CE

HWANG, PM

FOTUHI, M

DAWSON, TM

SNYDER, SH

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205

来源：

NEURON | 1991年 / 7卷 / 04期

关键词：

D O I：

10.1016/0896-6273(91)90374-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nitric oxide is a free radical that has been recently recognized as a neural messenger molecule. Nitric oxide synthase has now been purified and molecularly cloned from brain. Using specific antibodies and oligonucleotide probes, we have localized brain nitric oxide synthase to discrete neuronal populations in the rat and primate brain. Nitric oxide synthase is exclusively neuronal, and its localization is absolutely coincident with NADPH diaphorase staining in both rat and primate.

引用

收藏

页码：615 / 624

页数：10

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