ESCAPE FROM X-INACTIVATION IN HUMAN AND MOUSE

被引：147

作者：

DISTECHE, CM

机构：

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 01期

关键词：

D O I：

10.1016/S0168-9525(00)88981-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genes that escape X inactivation have been recently found in human and kt mouse. Although many of these genes have homologues on the Y chromosome that may compensate for expression from both X alleles in females, some have no Y homologues, and this presumably results In dosage differences between the sexes. Comparisons between human and mouse have revealed that the X-inactivation status of some genes differs significantly between the two species, suggesting continuous evolutionary changes in the sex chromosomes. Questions about the mechanisms of 'escape' are relevant to tbe understanding of gene regulation by X inactivation.

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页码：17 / 22

页数：6

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