ROLE OF HUMORAL AGENTS IN VOLUME EXPANDED HYPERTENSION

被引：469

作者：

HADDY, FJ ^{[1
]}

OVERBECK, HW ^{[1
]}

机构：

[1] MICHIGAN STATE UNIV, DEPT PHYSIOL, E LANSING, MI 48824 USA

来源：

LIFE SCIENCES | 1976年 / 19卷 / 07期

关键词：

EXPERIMENTAL RENAL-HYPERTENSION; NA-K-ATPASE; POTASSIUM ADENOSINE-TRIPHOSPHATASE; RENOMEDULLARY INTERSTITIAL-CELLS; EXTRACELLULAR FLUID VOLUME; ONE-KIDNEY HYPERTENSION; VASCULAR-RESISTANCE; SODIUM-TRANSPORT; CARDIAC-OUTPUT; VASODILATOR RESPONSES;

D O I：

10.1016/0024-3205(76)90284-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Increased salt intake or decreased salt excretion [in animals and humans] leads to elevated blood pressure and increased extracellular salt and volume. The blood pressure rises slowly and for this reason and others cannot be explained by the increased salt or volume per se. It appears that pressure rises as a result of some indirect effect of the increased volume. Autoregulation was implicated, but reasons are presented which make this an unlikely possibility. Recent evidence suggests that some humoral agent or agents, operating through the Na+-K+ pump in cardiovascular muscle, participate in the genesis of volume expanded hypertension.

引用

页码：935 / 948

页数：14

共 119 条

[21] CIRCULATING CATECHOLAMINE LEVELS IN HUMAN AND EXPERIMENTAL HYPERTENSION [J].

DECHAMPLAIN, J ;

FARLEY, L ;

COUSINEAU, D ;

VANAMERINGEN, MR .

CIRCULATION RESEARCH, 1976, 38 (02) :109-114

[22]

DOUGLAS JR, 1976, J PHARMACOL EXP THER, V196, P35

[23] DEVELOPMENT AND MAINTENANCE OF RENAL-HYPERTENSION IN NORMAL AND GUANETHIDINE SYMPATHECTOMIZED RATS [J].

DOUGLAS, JR ;

JOHNSON, EM ;

MARSHALL, GR ;

HEIST, J ;

HARTMAN, BK ;

NEEDLEMAN, P .

CIRCULATION RESEARCH, 1975, 36 (06) :171-178

[24]

EDMONDSON RPS, 1975, LANCET, V1, P1003

[25]

EMERSON TE, 1970, AM J PHYSIOL, V218, P234

[26]

ESPINEL CH, 1975, CLIN RES, V23, pA35

[27] INHIBITOR OF SODIUM-TRANSPORT IN URINE OF DOGS WITH NORMAL RENAL-FUNCTION [J].

FAVRE, H ;

HWANG, KH ;

SCHMIDT, RW ;

BRICKER, NS ;

BOURGOIGNIE, JJ .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (05) :1302-1311

[28] INCREASED CARDIAC OUTPUT AS A CONTRIBUTORY FACTOR IN EXPERIMENTAL RENAL HYPERTENSION IN DOGS [J].

FERRARIO, CM ;

PAGE, IH ;

MCCUBBIN, JW .

CIRCULATION RESEARCH, 1970, 27 (05) :799-&

[29] CONTRIBUTION OF CARDIAC-OUTPUT AND PERIPHERAL RESISTANCE TO EXPERIMENTAL RENAL-HYPERTENSION [J].

FERRARIO, CM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1974, 226 (03) :711-717

[30] ROLE OF MEDULLARY NA-K-ATPASE IN RENAL POTASSIUM ADAPTATION [J].

FINKELSTEIN, FO ;

HAYSLETT, JP .

AMERICAN JOURNAL OF PHYSIOLOGY, 1975, 229 (02) :524-528

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