LITHIUM AUGMENTATION IN ANTIDEPRESSANT-RESISTANT PATIENTS - A QUANTITATIVE-ANALYSIS

被引：98

作者：

AUSTIN, MPV

SOUZA, FGM

GOODWIN, GM

机构：

[1] ROYAL EDINBURGH & ASSOC HOSP, MRC, BRAIN METAB UNIT, MORNINGSIDE PK, EDINBURGH EH10 5HF, SCOTLAND

[2] UNIV EDINBURGH, ROYAL EDINBURGH HOSP, DEPT PSYCHIAT, EDINBURGH EH8 9YL, MIDLOTHIAN, SCOTLAND

[3] STATE UNIV CEARA, MESSEJANA MENTAL HLTH HOSP, FORTALEZA, BRAZIL

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1991年 / 159卷

关键词：

D O I：

10.1192/bjp.159.4.510

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A quantitative analysis was used to examine the efficacy of lithium augmentation in the acute treatment of depressed patients resistant to a standard trial of an antidepressant. Effect sizes were measured by the odds ratio using the Mantel-Haenszel method. Only controlled trials were included in order to minimise bias in method. A highly statistically significant effect for lithium augmentation was found, the pooled odds ratio being 0.146 and its 95% confidence interval 0.05-0.44 (i.e. the odds of remaining ill are reduced by between 56% and 95% with the use of lithium treatment). While these results support the case for lithium augmentation in treatment-resistant depression, there remains considerable uncertainty over the duration of treatment necessary to see and sustain the treatment response.

引用

页码：510 / 514

页数：5

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