Estimation of the microcirculation state in cerebrovascular disorders using laser doppler flowmetry data and hemorheological parameters

被引：2

作者：

I. A. Tikhomirova

S. G. Mikhailova

S. V. Lychenko

A. O. Oslyakova

机构：

[1] Ushinskii State Pedagogical University, Yaroslavl

[2] Ministry of Health and Social Development, Yaroslavl State Medical Academy, Yaroslavl

来源：

Human Physiology | 2012年 / 38卷 / 1期

关键词：

cerebrovascular accident (CVA); hemorheology; laser Doppler flowmetry; microcirculation; regulatory mechanisms;

D O I：

10.1134/S0362119711060156

中图分类号：

学科分类号：

摘要：

The microcirculation state was assessed in the group of patients with ischemic stroke (n = 30) and the control group of healthy individuals (n = 27) using laser Doppler flowmetry and the wavelet analysis of the amplitude-frequency range of microvascular blood flow oscillations combined with absorption spectroscopy. The hemorheological parameters (blood and plasma viscosity, the degree of red blood cell aggregability and deformability) were assessed in both groups, as were their correlations with the microcirculation parameters. Decreased tissue perfusion (by 25%) and specific oxygen consumption (by 21%) were revealed in a cerebrovascular accident. Changes in the tone-forming regulatory mechanisms of microcirculation of vasodilating nature (decreased microvascular tone, activation of the secretory function of endothelium) may be regarded as a compensatory reaction aimed at maintaining the blood supply of organs and tissues in stroke. The blood viscosity increase in patients due to the plasma viscosity increase and increased red blood cell aggregability and their decreased deformability cause the blood flow to slow down and the wall shear stress to increase, which activates the endothelial secretory function and vasodilation of microvessels. Correlation between the rheological parameters and the passive (respiratory and cardiac) rhythm amplitudes was observed in the control group. In patients, the hemorheological parameters were correlated with the characteristics of the active factors of microvascular blood flow modulation (endothelial, neurogenic, and myogenic), which confirms the role of changed blood properties and regulatory tone-forming mechanisms in the maintenance of tissue perfusion in cerbrovascular accidents. © 2012 Pleiades Publishing, Ltd.

引用

页码：56 / 62

页数：6

共 23 条

[11]

Lazernaya Dopplerovskaya Fluometriya Mikrotsirkulyatsii Krovi. Rukovodstvo Dlya Vrachei (Laser Doppler Flowmetry of Blood Microcirculation. Doctor Manual), (2005)

[12]

Bran'ko V.V., Bogdanova E.A., Kamshilina L.S., Et al., Metod Lazernoi Dopplerovskoi Fluometrii V Kardiologii. Posobie Dlya Vrachei (Method of Laser Doppler Flowmetry in Cardiology. Doctor Manual), (1999)

[13]

Fedorovich A.A., Functional State of the Regulatory Mechanisms of Microcirculatory Blood Flow in Health and in Arterial Hypertension as Evidenced by the Laser Doppler Flowmetry Data, Reg. Krovoobr. Mikrotsirk., 9, 133, (2010)

[14]

Szygula R., The Changes in Cutaneous Microcirculation in Judo Athletes before the Preparation Period and in the Competition Period, Med. Sport., 12, 1, (2008)

[15]

Murav'ev A.V., Cheporov S.V., Gemoreologiya (Eksperimental'nye I Klinicheskie Aspekty Reologii Krovi (Hemorheology: Experimental and Clinical Aspects of Blood Rheology), (2009)

[16]

Stoltz J.F., Donner M., Muller S., Hemorheology in Practice: An Introduction to the Concept of a Hemorheological Profile, Rev. Port. Hemorheol., 5, 2, (1991)

[17]

Reid H.L., Dormandy J.A., Barnes A.J., Et al., Impaired Red Cell Deformability in Peripheral Vascular Diseases, Lancet, 1, (1976)

[18]

Hardeman M.R., Goedhart P.T., Shin S., Methods in Hemorheology, Handbook of Hemorheology and Hemodynamics, IOS, (2007)

[19]

Sergienko V.I., Bondareva I.B., Matematicheskaya statistika v klinicheskikh issledovaniyakh (Mathematical Statistics in Clinical Investigations), (2006)

[20]

Krupatkin A.I., Pulse and Respiratory Blood Flow Oscillations in the Skin Microcirculatory Bed, Fiziol. Chel., 34, 3, (2008)

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