Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2

被引：158

作者：

Dearth, Robert K.

Cui, Xiaojiang

Kim, Hyun-Jung

Hadsell, Darryl L.

Lee, Adrian V. ^{[1
]}

机构：

[1] Baylor Coll Med, Breast Ctr, Dept Med, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Dept Pediat, Houston, TX 77030 USA

来源：

CELL CYCLE | 2007年 / 6卷 / 06期

关键词：

insulin receptor substrate; IRS-1; IRS-2; breast cancer; mammary gland; transgenic mouse; cancer; transformation; oncogene;

D O I：

10.4161/cc.6.6.4035

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin receptor substrates (IRSs) are adaptor proteins that link signaling from upstream activators to multiple downstream effectors to modulate normal growth, metabolism, survival, and differentiation. Recent cell culture studies have shown that IRSs can interact with, and are functionally required for, the transforming ability of many oncogenes. Consistent with this, IRSs are elevated and hyperactive in many human tumors. IRSs respond to many extracellular signals that are critical for mammary gland development, and we have shown that IRSs disrupt normal mammary acini formation in vitro, and cause mammary tumorigenesis and metastasis in vivo. In this review we will discuss the role of IRSs in both transformation and cancer progression.

引用

收藏

页码：705 / 713

页数：9

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