Epidermal growth factor receptor: mechanisms of activation and signalling

被引：1270

作者：

Jorissen, RN

Walker, F

Pouliot, N

Garrett, TPJ

Ward, CW

Burgess, AW ^{[1
]}

机构：

[1] Ludwig Inst Canc Res, Parkville, Vic, Australia

[2] CSIRO, Hlth Sci & Nutr, Parkville, Vic 3052, Australia

[3] Cooperat Res Ctr Cellular Growth Factors, Parkville, Vic 3050, Australia

[4] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

来源：

EXPERIMENTAL CELL RESEARCH | 2003年 / 284卷 / 01期

关键词：

D O I：

10.1016/S0014-4827(02)00098-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-a, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes. (C) 2003 Elsevier Science (USA). All rights reserved.

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页码：31 / 53

页数：23

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