Li-Doped Ti Surface for the Improvement of Osteointegration

被引：10

作者：

Qiu, Longhai ^{[1
,2
]}

Zhu, Zhanbei ^{[2
]}

Peng, Feng ^{[2
]}

Zhang, Chi ^{[2
]}

Xie, Juning ^{[2
]}

Zhou, Ruixiang ^{[2
]}

Zhang, Yu ^{[1
,2
]}

Li, Mei ^{[2
]}

机构：

[1] Southern Med Univ, Sch Clin Med 2, Guangzhou 510515, Peoples R China

[2] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Orthoped, Med Res Ctr, Guangzhou 510080, Peoples R China

来源：

ACS OMEGA | 2022年 / 7卷 / 14期

关键词：

PLASMA ELECTROLYTIC OXIDATION; LITHIUM; TITANIUM; OSSEOINTEGRATION; CARTILAGE; BEHAVIOR; SCAFFOLD;

D O I：

10.1021/acsomega.2c00229

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. In vitro results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furthermore, a bone implantation model indicated that the Li-doped Ti surface showed improved osteointegration. The incorporation of Li into a Ti surface is a promising method for orthopedic applications.

引用

页码：12030 / 12038

页数：9

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