Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

被引：59

作者：

De Fusco, Carolina ^{[1
,2
]}

Messina, Antonietta ^{[1
,2
]}

Monda, Vincenzo ^{[1
,2
]}

Viggiano, Emanuela ^{[1
,2
,3
]}

Moscatelli, Fiorenzo ^{[4
]}

Valenzano, Anna ^{[4
]}

Esposito, Teresa ^{[1
,2
]}

Sergio, Chieffi ^{[1
,2
]}

Cibelli, Giuseppe ^{[4
]}

Monda, Marcellino ^{[1
,2
]}

Messina, Giovanni ^{[1
,2
,4
]}

机构：

[1] Univ Naples 2, Dept Expt Med, Sect Human Physiol, 16 Costantinopoli Str, I-80138 Naples, Italy

[2] Univ Naples 2, Unit Dietet & Sport Med, 16 Costantinopoli Str, I-80138 Naples, Italy

[3] Univ Padua, Dept Med, Padua, Italy

[4] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

来源：

STEM CELLS INTERNATIONAL | 2017年 / 2017卷

关键词：

BODY-MASS INDEX; INSULIN-RESISTANCE; MINERAL DENSITY; STEM-CELLS; FAT; OBESITY; MARROW; OSTEOCALCIN; OSTEOPOROSIS; WOMEN;

D O I：

10.1155/2017/4045238

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.

引用

页数：6

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