Genomic circuits and the integrative biology of cardiac diseases

被引:150
作者
Chien, KR [1 ]
机构
[1] Univ Calif San Diego, Salk Program Mol Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Inst Mol Med, La Jolla, CA 92093 USA
关键词
D O I
10.1038/35025196
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Human cardiac disease is the result of complex interactions between genetic susceptibility and environmental stress. The challenge is to identify modifiers of disease, and to design new therapeutic strategies to interrupt the underlying disease pathways. The availability of genomic databases for many species is uncovering networks of conserved cardiac-specific genes within given physiological pathways. A new classification of human cardiac diseases can be envisaged based on the disruption of integrated genomic circuits that control heart morphogenesis, myocyte survival, biomechanical stress responses, cardiac contractility and electrical conduction.
引用
收藏
页码:227 / 232
页数:6
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