LDL-receptor structure - Calcium cages, acid baths and recycling receptors

被引：152

作者：

Brown, MS

Herz, J

Goldstein, JL

机构：

[1] University of Texas Southwestern Medical Center,Department of Molecular Genetics

来源：

NATURE | 1997年 / 388卷 / 6643期

关键词：

D O I：

10.1038/41672

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The low-density lipoprotein receptor (LDLR) removes cholesterol-carrying lipoproteins from the blood, and mutations in this protein lead to familial hypercholesterolaemia -- a condition that leads to high cholesterol levels and heart attacks at an early age. We're now a step closer to knowing why these mutations are so damaging thanks to a study of one region of the receptor, mutations in which destabilize the whole protein.

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页码：629 / 630

页数：2

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