ACID-DEPENDENT LIGAND DISSOCIATION AND RECYCLING OF LDL RECEPTOR MEDIATED BY GROWTH-FACTOR HOMOLOGY REGION

被引：364

作者：

DAVIS, CG

GOLDSTEIN, JL

SUDHOF, TC

ANDERSON, RGW

RUSSELL, DW

BROWN, MS

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT INTERNAL MED,DALLAS,TX 75235

[2] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT CELL BIOL,DALLAS,TX 75235

来源：

NATURE | 1987年 / 326卷 / 6115期

关键词：

D O I：

10.1038/326760a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ligand binding. © 1987 Nature Publishing Group.

引用

页码：760 / 765

页数：6

共 27 条

[1]

BEISIEGEL U, 1981, J BIOL CHEM, V256, P1923

[2] LIPOPROTEIN RECEPTORS IN THE LIVER - CONTROL SIGNALS FOR PLASMA-CHOLESTEROL TRAFFIC [J].