Risk Factors for Gastrointestinal Ulcer Disease in the US Population

被引:71
作者
Garrow, Donald [1 ]
Delegge, Mark H. [1 ]
机构
[1] Med Univ S Carolina, Div Gastroenterol & Hepatol, Dept Med, Charleston, SC 29425 USA
关键词
Gastrointestinal ulcer; Obesity; Coronary disease; COPD; Renal insufficiency; Diabetes; HELICOBACTER-PYLORI INFECTION; CHRONIC ALCOHOL INGESTION; PEPTIC-ULCER; DUODENAL-ULCER; GASTRIC-ULCER; UNITED-STATES; ETHNIC-DIFFERENCES; DIABETES-MELLITUS; HEART-DISEASE; FREE-RADICALS;
D O I
10.1007/s10620-008-0708-x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose Gastrointestinal (GI) ulcers are frequently seen in patients with multiple chronic medical conditions. Few studies have described the overall prevalence, comorbidities, or risk factors associated with this diagnosis. We sought to determine among a national dataset if individuals with certain medical comorbidities are at increased risk for gastrointestinal ulcer disease, while controlling for relevant confounders. Results The overall prevalence of GI ulcer is 8.4%. A significant increased risk of ulcer history is associated with older age (OR 1.67), African-Americans (OR 1.20) current (OR 1.99) and former (OR 1.55) tobacco use, former alcohol use (OR 1.29), obesity (OR 1.18), chronic obstructive pulmonary disease (OR 2.34), chronic renal insufficiency (OR 2.29), coronary heart disease (OR 1.46), and three or more doctor visits in a year (OR 1.49). Conclusions This large US population-based study reports on a number of demographic, behavioral, and chronic medical conditions associated with higher risk of gastrointestinal ulcer disease.
引用
收藏
页码:66 / 72
页数:7
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