Recent pharmacological studies on natural products in China

被引：103

作者：

Zhu, XZ ^{[1
]}

Li, XY ^{[1
]}

Liu, J ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2004年 / 500卷 / 1-3期

关键词：

natural product; huperzine A; s-(-)-3-n-butylphthalide; (-)-clausenamide; Ginkgo biloba extract;

D O I：

10.1016/j.ejphar.2004.07.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural products have been used as medicinal agents for many years. In addition, these compounds have also served as the starting points for semisynthetic analogs with improved properties. This review focuses on recent advances in the pharmacological studies on natural products mainly performed and published in China. Emphasis will be placed on those compounds that show the greatest promise clinically such as huperzine A (9-amino-13-ethylidene-11-methyl-4-azatricyclo[7.3.1.0(3.8)]trideca-3(8),6,11-trien-5-one), s-(-)-3-n-butylphthalide (s-(-)-3-butyl-1(3H)-isobenzofuranone), (-)-clausenamide (3-hydroxy-4-phenyl-5alpha-hydroxybenzyl-N-methyl-gamma-lactam) and Ginkgo biloba extract and its active components. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：221 / 230

页数：10

共 108 条

[51] Effect of huperzine A on working memory in reserpine- or yohimbine-treated monkeys [J].

Ou, LY ;

Tang, XC ;

Cai, JX .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 433 (2-3) :151-156

[52]

PU LX, 1990, ACTA PHARM SINIC, V11, P76

[53] Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine [J].

Qin, Z ;

Xi, CT .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 455 (2-3) :101-107

[54] Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation [J].

Qiu, DM ;

Zhao, GH ;

Aoki, Y ;

Shi, LF ;

Uyei, A ;

Nazarian, S ;

Ng, JCH ;

Kao, PN .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) :13443-13450

[55] GLUTAMATE INDUCES THE PRODUCTION OF REACTIVE OXYGEN SPECIES IN CULTURED FOREBRAIN NEURONS FOLLOWING NMDA RECEPTOR ACTIVATION [J].

REYNOLDS, IJ ;

HASTINGS, TG .

JOURNAL OF NEUROSCIENCE, 1995, 15 (05) :3318-3327

[56]

Satoh T, 1997, J NEUROSCI RES, V50, P413, DOI 10.1002/(SICI)1097-4547(19971101)50:3<413::AID-JNR7>3.0.CO

[57]

2-L

[58] Galantamine - A review of its use in Alzheimer's disease [J].

Scott, LJ ;

Goa, KL .

DRUGS, 2000, 60 (05) :1095-1122

[59] Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii [J].

Shamon, LA ;

Pezzuto, JM ;

Graves, JM ;

Mehta, RR ;

Wangcharoentrakul, S ;

Sangsuwan, R ;

Chaichana, S ;

Tuchinda, P ;

Cleason, P ;

Reutrakul, V .

CANCER LETTERS, 1997, 112 (01) :113-117

[60] The neuroprotective properties of the Ginkgo biloba leaf: A review of the possible relationship to platelet-activating factor (PAF) [J].

Smith, PF ;

Maclennan, K ;

Darlington, CL .

JOURNAL OF ETHNOPHARMACOLOGY, 1996, 50 (03) :131-139

← 1 2 3 4 5 6 7 8 9 10 →