Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes

被引：254

作者：

Fukushima, M ^{[1
]}

Suzuki, H ^{[1
]}

Seino, Y ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Diabet & Clin Nutr, Sakyo Ku, Kyoto 6068507, Japan

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2004年 / 66卷

关键词：

insulin secretion; insulin sensitivity; insulinogenic index; HOMA-IR; ISI composite;

D O I：

10.1016/j.diabres.2003.11.024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have examined the contribution of insulin secretion and insulin resistance to glucose intolerance in Japanese. Some indices of insulin secretion and insulin sensitivity based on the results of OGTT were used. The decline of insulin secretion capacity was significant throughout the development of glucose intolerance from NGT via IGT to DM. Decreased insulinogenic indices were conspicuous when it is compared with other types of diabetes. Slight impairment of insulin secretion has begun in subjects with NGT. The progression from NGT via isolated IGT to isolated post-challenge hyperglycemia was considered mostly due to the deterioration of early-phase insulin secretion. It is summazied that decreased insulin secretion capacity takes a definite role in the development from NGT to type 2 diabetes in Japan. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：S37 / S43

页数：7

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