Angiogenesis assays: Problems and pitfalls

被引：114

作者：

Auerbach, R ^{[1
]}

Akhtar, N ^{[1
]}

Lewis, RL ^{[1
]}

Shinners, BL ^{[1
]}

机构：

[1] Univ Wisconsin, Dev Biol Lab, Madison, WI 53705 USA

来源：

CANCER AND METASTASIS REVIEWS | 2000年 / 19卷 / 1-2期

关键词：

angiogenesis; methodology; animal models; assay;

D O I：

10.1023/A:1026574416001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many studies of angiogenesis inducers and inhibitors rely on in vitro or in vivo models as indicators of efficacy. However, as valuable as these models are, there are limitations to each one of these. This overview describes some of the principal methods now in use and discusses the advantages and some of the limitations of these methods. It is suggested that multiple assays, involving both in vitro and in vivo assays, are at present the best way to minimize the problems inherent in any specific assay.

引用

页码：167 / 172

页数：6

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