An overview of the Notch signalling pathway

被引：281

作者：

Baron, M ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2003年 / 14卷 / 02期

基金：

英国惠康基金;

关键词：

Notch; proteolysis; presenilin; ubiquitination;

D O I：

10.1016/S1084-9521(02)00179-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Notch receptor plays a key role in modulating cell fate decisions throughout the development of invertebrate and vertebrate species. Four Notch homologues have been identified in the human genome and aberrant Notch function has been associated with a number of human diseases. An intriguing pathway of Notch signalling has been elucidated involving multiple proteolytic steps and this pathway offers several targets for potential therapeutic intervention. While a consensus model has emerged, in the details there is much that is contentious. This review will primarily focus on our current understanding of the proteolytic events involved in generating and regulating Notch signalling. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：113 / 119

页数：7

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