Gastric cancer originating from bone marrow-derived cells

被引：903

作者：

Houghton, J ^{[1
]}

Stoicov, C

Nomura, S

Rogers, AB

Carlson, J

Li, HC

Cai, X

Fox, JG

Goldenring, JR

Wang, TC

机构：

[1] Univ Massachusetts, Sch Med, Dept Med & Canc Biol, Worcester, MA 01605 USA

[2] Vanderbilt Univ, Sch Med, Dept Surg, Epithelial Biol Program, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[4] Univ Tokyo, Grad Sch Med, Dept Gastrointestinal Surg, Bunkyo Ku, Tokyo 1138655, Japan

[5] MIT, Div Comparat Med, Cambridge, MA 02139 USA

[6] Vet Adm Med Ctr, Nashville, TN 37232 USA

来源：

SCIENCE | 2004年 / 306卷 / 5701期

关键词：

D O I：

10.1126/science.1099513

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.

引用

页码：1568 / 1571

页数：4

共 18 条

[1] Can stem cells cross lineage boundaries? [J].

Anderson, DJ ;

Gage, FH ;

Weissman, IL .

NATURE MEDICINE, 2001, 7 (04) :393-395

[2] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[3] Pathology of mouse models of intestinal cancer: Consensus report and recommendations [J].

Boivin, GP ;

Washington, K ;

Yang, K ;

Ward, JM ;

Pretlow, TP ;

Russell, R ;

Besselsen, DG ;

Godfrey, VL ;

Doetschman, T ;

Dove, WF ;

Pitot, HC ;

Halberg, RB ;

Itzkowitz, SH ;

Groden, J ;

Coffey, RJ .

GASTROENTEROLOGY, 2003, 124 (03) :762-777

[4]

Clouston AD, 2001, PATHOLOGY, V33, P271

[5] Medicine - Tracing the steps of metastasis, cancer's menacing ballet [J].

Couzin, J .

SCIENCE, 2003, 299 (5609) :1002-+

[6]

Fox JG, 2003, CANCER RES, V63, P942

[7]

Fox JG, 2002, CANCER RES, V62, P696

[8] Reversible drug-induced oxyntic atrophy in rats [J].

Goldenring, JR ;

Ray, GS ;

Coffey, RJ ;

Meunier, PC ;

Haley, PJ ;

Barnes, TB ;

Car, BD .

GASTROENTEROLOGY, 2000, 118 (06) :1080-1093

[9] Pluripotency of mesenchymal stem cells derived from adult marrow [J].

Jiang, Yuehua ;

Jahagirdar, Balkrishna N. ;

Reinhardt, R. Lee ;

Schwartz, Robert E. ;

Keene, C. Dirk ;

Ortiz-Gonzalez, Xilma R. ;

Reyes, Morayma ;

Lenvik, Todd ;

Lund, Troy ;

Blackstad, Mark ;

Du, Jingbo ;

Aldrich, Sara ;

Lisberg, Aaron ;

Low, Walter C. ;

Lergaespada, David A. ;

Verfaillie, Catherine M. .

Nature, 2002, 418 (6893) :41-49

[10] Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell [J].

Krause, DS ;

Theise, ND ;

Collector, MI ;

Henegariu, O ;

Hwang, S ;

Gardner, R ;

Neutzel, S ;

Sharkis, SJ .

CELL, 2001, 105 (03) :369-377

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