Can stem cells cross lineage boundaries?

被引：370

作者：

Anderson, DJ ^{[1
]}

Gage, FH

Weissman, IL

机构：

[1] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

[2] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[3] Stanford Univ, Stanford, CA 94305 USA

来源：

NATURE MEDICINE | 2001年 / 7卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/86439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stem cells have traditionally been characterized as either embryonic (pluripotent) or organ-specific. Recent work suggests that the latter can "transdifferentiate" into other cell types, carrying significant implications for possible clinical use of these cells. Here the authors critically examine the existing data, and suggest standards for the evaluation of these and future studies.

引用

页码：393 / 395

页数：3

共 20 条

[1] Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo [J].

Bjornson, CRR ;

Rietze, RL ;

Reynolds, BA ;

Magli, MC ;

Vescovi, AL .

SCIENCE, 1999, 283 (5401) :534-537

[2] Generalized potential of adult neural stem cells [J].

Clarke, DL ;

Johansson, CB ;

Wilbertz, J ;

Veress, B ;

Nilsson, E ;

Karlström, H ;

Lendahl, U ;

Frisén, J .

SCIENCE, 2000, 288 (5471) :1660-1663

[3] GROWTH-FACTOR REGULATION OF MOUSE PRIMORDIAL GERM-CELL DEVELOPMENT [J].

DONOVAN, PJ .

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 29, 1994, 29 :189-225

[4] Muscle regeneration by bone marrow derived myogenic progenitors [J].

Ferrari, G ;

Cusella-De Angelis, G ;

Coletta, M ;

Paolucci, E ;

Stornaiuolo, A ;

Cossu, G ;

Mavilio, F .

SCIENCE, 1998, 279 (5356) :1528-1530

[5] Stem cells: A new lease on life [J].

Fuchs, E ;

Segre, JA .

CELL, 2000, 100 (01) :143-155

[6] Mammalian neural stem cells [J].

Gage, FH .

SCIENCE, 2000, 287 (5457) :1433-1438

[7] Skeletal myogenic potential of human and mouse neural stem cells [J].

Galli, R ;

Borello, U ;

Gritti, A ;

Minasi, AG ;

Bjornson, C ;

Coletta, M ;

Mora, M ;

De Angelis, MGC ;

Fiocco, R ;

Cossu, G ;

Vescovi, AL .

NATURE NEUROSCIENCE, 2000, 3 (10) :986-991

[8] Dystrophin expression in the mdx mouse restored by stem cell transplantation [J].

Gussoni, E ;

Soneoka, Y ;

Strickland, CD ;

Buzney, EA ;

Khan, MK ;

Flint, AF ;

Kunkel, LM ;

Mulligan, RC .

NATURE, 1999, 401 (6751) :390-394

[9] Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells [J].

Kondo, T ;

Raff, M .

SCIENCE, 2000, 289 (5485) :1754-1757

[10] Purified hematopoietic stem cells can differentiate into hepatocytes in vivo [J].

Lagasse, E ;

Connors, H ;

Al-Dhalimy, M ;

Reitsma, M ;

Dohse, M ;

Osborne, L ;

Wang, X ;

Finegold, M ;

Weissman, IL ;

Grompe, M .

NATURE MEDICINE, 2000, 6 (11) :1229-1234

← 1 2 →